Finally got onto Skyrush today, and didn't experience any of the thigh pain people are talking about. I do a lot of weight lifting so I have pretty big legs, so I was expecting some pain, but was pleasantly surprised. Loved the ride though.
One odd thing I noticed, Fahrenheit seemed to have a way longer line all day than Skyrush did. Super Dooper Looper did too, though that may have been because they were running one train.