I'm confused on how they are going to do this. I know they will use the actors voices, but how is the audience going to interact with the show?
Maybe they could choose random people out of the audience to go up on the stage and help with trying to solve the mystery. Who knows they might just have performers act out some crime and when it's over they'll ask who did it. Then the audience could clap the loudest for who they think it was.
By the way I like the idea about the "Where's Tweety?" thing. It would add a great family aspect to the show, but on the other hand something about CSI and Tweety being kidnaped doesn't seem to mix.